Case reports

Manuscripts must be completed double-spaced, font size 12-Cambria and lines should be numbered for review purposes. Make sure that line numbers are assigned continuously, starting from the abstract. Please insert page numbers in the bottom, right-hand corner of each successive page beginning at the second page (do not assign a page number to the Title page). All files (except illustrative elements) should be uploaded as Microsoft Word documents.

Please consult the CARE guidelines that support transparency and accuracy in the publication of case reports and the reporting of information from patient encounters. (Gagnier J, Kienle G, Altman DG, Moher D, Sox H, Riley DS, and the CARE group. The CARE guidelines: consensus-based clinical case report guideline development. Journal of Clinical Epidemiology;67(1),46-51.)

Title page

The following informative units are compulsory:

  • Title. The title should be concise and informative. It accurately represents the case and includes the words “case report” or “testimonial”. Be cautious on using abbreviations and formulae.
  • Author(s) information: The professional background of each contributor should be listed, including years of professional expertise. Please provide the e-mail addresses and full contact details of all authors, including postal address, telephone number and institutional addresses. Clearly indicate who will handle correspondence.
  • Word count: Please add the number of manuscript words, excluding abstracts, acknowledgements, tables, figures and references.
  • Informed consent: obtaining informed consent of the patient or his/her caretaker is compulsory.
  • Conflict of interest declaration: Conflict of interests information for each author (both author’s conflict of interests and sources of support for the work) should be summarized on the title page and presented in further detail on the conflict of interest form.

Manuscript structure

We strongly advise you to build your manuscript as follows:

1. Abstract
This paragraph offers a concise and balanced reflection of the contents of the case report and is subdivided in four sections.
Introduction: elaborates briefly on the background of the single case: why is this case report important? What makes it unique?
Case presentation: a short description of the patient: main symptoms, diagnosis/health condition, age, sex, ethnicity,
Therapeutic intervention: describe the therapeutic intervention(s) and main outcomes. Conclusion: summarize your conclusions and their clinical implications.

Keywords: please add two to seven keywords that do not appear in the title of the document and identify areas covered in this case report. Abbreviations or ambiguous terms are not allowed.

2. Introduction
Situate your case in a broader context, familiarize the recipient with the disease/health condition, the prevalence, symptoms and prognosis. The introduction should conclude with a clear statement of what is being reported in the article.

3. Patient: case presentation(s)
Introduce the case and describe the patient characteristics in a concise and chronological order. If the case is part of a case series, all relevant details should be provided for all patients. Please include the following details:

  • The primary complaint/symptoms, demographic information and other patient specific details such as medical, family and psychosocial history (relevant family, occupational, social, allergies, etc.).
  • A physical examination and other significant clinical findings: vital signs presented at examination, other investigations and results. Please provide enough quantitative and qualitative information to facilitate an assessment of the validity of the results and conclusions.
  • Diagnostic methods, diagnoses considered and prognostic characteristics.
  • Comorbid conditions.

4. Therapeutic intervention
A description of the therapeutic intervention(s) applied, outcomes and unanticipated events.

  • Types of intervention.
  • Administration of the intervention (dosage, frequency, duration).
  • Intervention adherence and tolerance, clinical course, follow-up results (patient reported outcomes as well as clinician assessed and reported outcomes).
  • Significant adverse events (if relevant).
  • Relevant previous or simultaneous interventions and their outcomes.

5. Discussion / conclusions
Main conclusions and a clear outline of their significance and clinical implications. Please describe if/how the case can provide insight into the etiology of a particular disease. Other details that may be reported:

  • List strengths and limitations in your approach to the case.
  • Discuss relevant medical literature.
  • Explore the significance of the results for future research and clinical practice.
  • Generalization
  • Conclusions and recommendations

6. Patient’s perspective
Whenever appropriate, the author can invite the patient to add a description of a case from his/her own perspective and share his/her perspective on the treatment(s).

7. Acknowledgements
Significant attributions can be acknowledged in this section.

8. References
Authors can cite published case reports or refer to original articles that are relevant to the case they are presenting. All sources should be documented accurately. References should be numbered in order of initial appearance in the text and appear in the reference list in numerical order, following the citation standards of the American Medical Association (AMA) reference citation format. For the complete style manual online please go to

The editor will check the accuracy of all reference citations. However, we want to stress the importance of checking all references before submitting the paper to the journal. Every reference listed should be cited in the text and vice versa.

Below please find an overview of the main AMA-guidelines [PDF – 337 kB]

Guideline Manuscript Preparation – Case Report [PDF – 809 kB]